Prevention from Doxorubicin Cardiotoxicity by Available Protective Agents in Iran
نویسنده
چکیده مقاله:
Doxorubicin, used in pediatric chemotherapy regimens, has cardiotoxic effects. Dexrazoxane is co-administrated with doxorubicin to prevent its cardiotoxicity. Here we have explored some alternative food or drugs to be used in absence of dexrazoxane since it’s not readily available in Iran at this time. Keywords: Pediatric, chemotherapy, doxorubicin, cardiotoxicity, dexrazoxane, Iran.
منابع مشابه
prevention from doxorubicin cardiotoxicity by available protective agents in iran
doxorubicin, used in pediatric chemotherapy regimens, has cardiotoxic effects. dexrazoxane is co-administrated with doxorubicin to prevent its cardiotoxicity. here we have explored some alternative food or drugs to be used in absence of dexrazoxane since it’s not readily available in iran at this time. keywords: pediatric, chemotherapy, doxorubicin, cardiotoxicity, dexrazoxane, iran.
متن کاملPrevention of chronic doxorubicin cardiotoxicity in beagles by liposomal encapsulation.
Antitumor drugs such as doxorubicin have been encapsulated into liposomes as a means of enhancing activity and reducing toxicity. The present study was initiated to determine whether chronically administered liposome-encapsulated doxorubicin would be less toxic than the free drug. Doxorubicin was prepared in positively charged cardiolipin liposomes, and 1.75 mg/kg was given i.v. to each of five...
متن کاملIn Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity
Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity. Our study was aimed to find out the protective effect of diosgenin against DOX-induced cardiotoxicity in mice. DOX treatment led to a significant decrease in the ratio of heart weight to body weight, and increases in the bloo...
متن کاملProtective effect of tetrandrine on doxorubicin-induced cardiotoxicity in rats.
AIMS AND BACKGROUND Doxorubicin (Dox) is effective in curative and adjuvant chemotherapy of malignant tumors. Cardiotoxicity is the chief toxic effect that limits the clinical use of Dox. We studied the effects of tetrandrine (Tet) on doxorubicin-induced cardiotoxicity in rats and its protective activity. MATERIALS AND METHODS Sprague-Dawley rats were randomly divided into the following 4 gro...
متن کاملProtective Effect of Ephedra nebrodensis on Doxorubicin-Induced Cardiotoxicity in Rats
Doxorubicin (DOX) is an anthracycline antibiotic with broad spectrum anti-tumour activity. Its effectiveness has been limited by the occurrence of dose-related myocardial and bone marrow toxicity. As oxidative stress is the main factor in DOX-induced cardiotoxicity, we presumed that agents which enhance endogenous antioxidants can prevent DOX induced cardiotoxicity. Animals received either DOX ...
متن کاملEffect of octreotide in the prevention of doxorubicin cardiotoxicity.
OBJECTIVE A precise method for prevention from doxorubicin cardiotoxicity is not known. We examined whether octreotide has a protective effect against doxorubicin cardiotoxicity. METHODS New Zealand rabbits (n=44) were divided into 4 groups according to drugs given: Group A (n=12) doxorubicin and octreotide, Group B (n=12) only doxorubicin, Group C (n=10) only octreotide and Group D (n=10) on...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 7 شماره None
صفحات 43- 44
تاریخ انتشار 2014-11
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023